In the struggle to manage body weight, different therapeutic approaches have been investigated. Elevated BMI (>30 kg/m 2) increases the risk of developing type 2 diabetes, hypertension, cholesterol abnormalities, CVD, Alzheimer's disease and inflammation-based pathologies ( Reference González-Castejón and Rodriguez-Casado 2 – Reference Profenno, Porsteinsson and Faraone 5 ). Scientific publications have showed that overweight is one of the major risks factors for metabolic syndrome disorders. The number of obese people has nearly doubled since 1980 and the WHO estimated in 2014 that more than 1♹ billion adults over 18 years of age were overweight, with more than 600 million being obese ( 1 ). Thus, a well-designed hydro-alcoholic extract of cashew apple could provide an attractive nutritional food ingredient to help support the management of body weight and associated metabolic parameters such as blood glucose and insulin levels.Īccording to the WHO, obesity and overweight are considered to be the fifth largest risk factor for global deaths. Furthermore, glycaemia, insulinaemia and insulin resistance (homeostasis model assessment-insulin resistance) of the DIO mice were significantly lowered compared with the control group. This was achieved without modifying their energy consumption. In both designs, the CAE significantly reduced body-weight gain and fat storage in both the peri-epididymal adipose tissue and the liver for mice under the HFD. For both experimental designs, body weight, peri-epididymal adipose tissue, liver weight, food consumption, glycaemia, insulinaemia and insulin resistance were assessed. Second, in the curative design, the animals were first maintained under the HFD for 4 weeks and then treated with the CAE for a further 4 weeks under the same regimen. First, in the preventive design, mice were treated orally with the CAE at the dose of 200 mg/kg body weight from the first day under a high-fat diet (HFD) and during 8 weeks thereafter. The present study was designed to evaluate the effect of a hydro-alcoholic extract of cashew apple (cashew apple extract CAE Cashewin ™) on obesity and diabetes, in two experimental designs using the diet-induced obesity (DIO) mouse model. Interestingly, however, cashew apple nutrients may have beneficial effects for health even if these are still poorly described. The cashew apple is an unvalued by-product from the cashew nut industry, of which millions of tonnes are simply discarded globally.

Cashew apple